Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 1342
interventional 1119
Observational 182
Registry 41

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 462
Biological 64
Drug|Radiation 62
Procedure 62
Biological|Drug 52
Device 52
Drug|Other 43
Drug|placebo 41
Radiation 32
Drug|Procedure 31
Other 27
Drug|Procedure|Radiation 18
Biological|Drug|Other 12
Drug|Other|Radiation 12
Diagnostic Test 11
Behavioral 10
Biological|Drug|Radiation 8
Biological|Other 8
Dietary Supplement 8
Behavioral|Other 6
Device|Drug 6
Biological|Drug|Procedure 5
Biological|Drug|Procedure|Radiation 5
Device|Procedure 5
Dietary Supplement|Drug 5
Drug|Other|placebo 5
Other|Procedure 5
Biological|Procedure 4
Drug|Other|Procedure|Radiation 4
Procedure|Radiation 4
Device|Other 3
Drug|Genetic 3
Drug|Other|Procedure 3
Genetic 3
Behavioral|Procedure 2
Biological|Drug|Other|Procedure 2
Biological|Drug|Other|Procedure|Radiation 2
Biological|placebo 2
Biological|Radiation 2
Combination Product 2
Combination Product|Drug 2
Diagnostic Test|Drug|Other 2
Behavioral|Drug|Genetic|Other|Procedure 1
Behavioral|Drug|Other 1
Behavioral|Drug|Other|Procedure 1
Behavioral|Drug|placebo 1
Behavioral|Other|Procedure 1
Biological|Device|Procedure 1
Biological|Drug|Genetic 1
Biological|Drug|Other|placebo 1
Biological|Drug|Other|Radiation 1
Biological|Other|Procedure 1
Biological|Procedure|Radiation 1
Device|Other|Procedure|Radiation 1
Device|Radiation 1
Diagnostic Test|Procedure 1
Dietary Supplement|Drug|Other 1
Dietary Supplement|Other 1
Drug|Genetic|Other 1
Drug|Genetic|Other|Procedure 1
Drug|Genetic|Other|Procedure|Radiation 1
Drug|placebo|Radiation 1
Other|placebo 1
Other|Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 608
China 73
Korea, Republic of 40
Italy 32
NA 29
France 27
Germany 27
United States|Canada 23
Canada 19
Netherlands 16
United Kingdom 16
Japan 12
Spain 12
Sweden 9
Denmark 8
Switzerland 5
Austria 4
Belgium 4
Israel 4
United States|United Kingdom 4
Australia 3
Brazil 3
Finland 3
United States|Israel 3
United States|Puerto Rico 3
United States|Taiwan 3
Hong Kong 2
India 2
Poland 2
Taiwan 2
United States|Australia 2
United States|India 2
United States|Russian Federation 2
United States|South Africa 2
Australia|Belgium|United Kingdom 1
Australia|Brazil|Bulgaria|Croatia|Germany|Hong Kong|India|Italy|Latvia|Lithuania|Malaysia|Mexico|Peru|Romania|Russian Federation|Singapore|Slovenia|Ukraine|United Kingdom 1
Australia|Canada|Czech Republic|Finland|France|Germany|Greece|Hungary|Italy|Japan|Sweden|Switzerland|United Kingdom 1
Australia|New Zealand|Spain 1
Australia|United Kingdom 1
Austria|Germany 1
Austria|Germany|Switzerland 1
Austria|Israel|Italy|Switzerland 1
Belarus 1
Belgium|Denmark|France|Germany|Ireland|Italy|Netherlands|Poland|Spain|United Kingdom 1
Belgium|Egypt|France|Germany|Netherlands|Poland|Turkey|United Kingdom 1
Belgium|France|Greece|India|Russian Federation|Slovakia|Tunisia|Ukraine 1
Belgium|France|Israel|Italy|Portugal 1
Belgium|Spain 1
Canada|Italy 1
Cuba 1
Cyprus 1
Cyprus|Ireland|Italy|Spain|United Kingdom 1
Czech Republic 1
Czech Republic|Hungary|Ukraine 1
Denmark|Finland|Norway|Sweden 1
Denmark|France|Germany|Greece|Israel|Netherlands|Switzerland 1
Denmark|Norway 1
Denmark|Romania 1
Egypt 1
France|Martinique 1
France|Monaco 1
Germany|Argentina|Australia|Austria|Belgium|Brazil|Canada|Croatia|Denmark|France|Greece|Hong Kong|Israel|Italy|Lithuania|Mexico|Poland|Romania|Serbia|Singapore|Spain|Taiwan|United Kingdom 1
Germany|Belgium|France|Israel|Netherlands|Switzerland 1
Germany|Hungary|Italy|Russian Federation|Spain|Ukraine 1
Germany|Switzerland 1
Greece|Netherlands 1
Hong Kong|Japan|Korea, Republic of|Malaysia|Philippines|Singapore|Taiwan 1
Iran, Islamic Republic of 1
Ireland 1
Ireland|Sweden 1
Italy|Netherlands|Slovakia|Spain 1
Japan|Korea, Republic of 1
Japan|Spain 1
Japan|Taiwan 1
Luxembourg 1
Malaysia 1
Mongolia 1
Norway 1
Norway|Spain|United Kingdom 1
Peru|Portugal|Italy|Netherlands|United States|Argentina|Australia|Austria|Belgium|Colombia|France|Germany|Greece|Spain|Sweden|Taiwan|United Kingdom|Venezuela 1
Portugal 1
Romania 1
Singapore 1
Singapore|Taiwan 1
Slovenia 1
South Africa 1
Spain|Australia|Austria|Belgium|Canada|China|Czech Republic|Finland|France|Germany|Israel|Italy|Netherlands|New Zealand|Peru|Poland|Singapore|South Africa|Sweden|Taiwan|United Kingdom 1
United States|Argentina|Australia|Austria|Belgium|Canada|France|Germany|Hong Kong|Hungary|India|Ireland|Italy|Japan|Korea, Republic of|Netherlands|Russian Federation|Singapore|South Africa|Spain|Sweden|Switzerland|Taiwan|United Kingdom 1
United States|Argentina|Australia|Belgium|Brazil|Canada|Chile|China|Germany|Greece|Hong Kong|Israel|Italy|Mexico|New Zealand|Poland|Romania|Singapore|United Kingdom 1
United States|Argentina|Australia|Belgium|Brazil|Canada|Chile|Germany|Greece|Israel|Italy|Mexico|New Zealand|Poland|Romania|Singapore|United Kingdom 1
United States|Argentina|Australia|Belgium|Canada|France|Germany|Italy|Netherlands|Spain|Sweden 1
United States|Argentina|Australia|Brazil|Canada|Czech Republic|France|Germany|Hungary|Italy|Korea, Republic of|South Africa|Spain|Taiwan|United Kingdom 1
United States|Argentina|Brazil|Bulgaria|Czech Republic|Hungary|India|Mexico|Romania|Russian Federation|Ukraine 1
United States|Australia|Austria|Belgium|Canada|Czech Republic|France|Germany|Hungary|Ireland|Italy|Poland|Romania|Russian Federation|United Kingdom 1
United States|Australia|Austria|Belgium|Canada|Czechia|Denmark|Finland|France|Germany|Hong Kong|Hungary|Ireland|Italy|Korea, Republic of|Netherlands|Portugal|Singapore|Spain|Taiwan|United Kingdom 1
United States|Australia|Austria|Belgium|Canada|France|Germany|Italy|Korea, Republic of|Poland|Spain|Taiwan|United Kingdom 1
United States|Australia|Belgium|Canada|France|Germany|Israel|Italy|Korea, Republic of|Netherlands|Spain|United Kingdom 1
United States|Australia|Belgium|Canada|France|Hong Kong|India|Italy|Japan 1
United States|Australia|Belgium|Canada|Germany|Netherlands|Spain 1
United States|Australia|Belgium|Canada|Germany|Spain 1
United States|Australia|Belgium|China|France|Germany|Hong Kong|Italy|Japan|Korea, Republic of|Netherlands|Poland|Singapore|Spain|Taiwan|United Kingdom 1
United States|Australia|Belgium|Italy|Japan|Netherlands|Spain|Sweden 1
United States|Australia|Bulgaria|Hungary|Romania 1
United States|Australia|Canada 1
United States|Australia|France|Ireland|Italy|Japan|Korea, Republic of|Spain|Taiwan 1
United States|Australia|Singapore 1
United States|Australia|Spain 1
United States|Belgium 1
United States|Belgium|Brazil|Canada|Chile|Colombia|Czech Republic|Finland|Germany|Hungary|India|Italy|Mexico|Norway|Peru|Poland|Russian Federation|Slovakia|Spain|Turkey|United Kingdom 1
United States|Belgium|Canada|France|Germany|Italy|Spain|United Kingdom 1
United States|Belgium|Canada|Germany|Spain 1
United States|Belgium|Canada|Israel 1
United States|Belgium|Canada|Italy|Japan|Korea, Republic of 1
United States|Belgium|Czechia|France|Germany|Italy|Norway|Poland|United Kingdom 1
United States|Belgium|Finland|France|Germany|Hong Kong|Italy|Japan|Korea, Republic of|Spain|Switzerland 1
United States|Belgium|France|Germany|Italy|Spain 1
United States|Belgium|France|Spain|United Kingdom 1
United States|Belgium|Singapore 1
United States|Belgium|United Kingdom 1
United States|Brazil 1
United States|Canada|Denmark|Germany|Italy|Japan|Korea, Republic of|Spain|Switzerland|Taiwan|United Kingdom 1
United States|Canada|France|Germany|Italy|Spain|United Kingdom 1
United States|Canada|France|Italy|Korea, Republic of|Netherlands|Norway|Singapore|Spain|Taiwan 1
United States|Canada|France|Italy|Spain 1
United States|Canada|France|Russian Federation|Spain 1
United States|Canada|Germany|Poland|Spain|United Kingdom 1
United States|Canada|Israel 1
United States|Canada|Israel|Norway|United Kingdom 1
United States|Canada|Israel|Portugal 1
United States|Canada|Puerto Rico 1
United States|China 1
United States|Czechia|France|Lebanon|Romania 1
United States|France|Hungary|Israel|Korea, Republic of|Romania|Russian Federation|Taiwan 1
United States|France|Italy|Korea, Republic of|Spain 1
United States|France|Korea, Republic of|Spain 1
United States|Germany 1
United States|Germany|Hungary|Netherlands 1
United States|Germany|Italy|Netherlands|Romania|Spain 1
United States|Germany|Spain 1
United States|Hungary|India|Russian Federation|Ukraine 1
United States|Japan 1
United States|Netherlands 1
United States|Norway|United Kingdom 1
United States|Singapore 1
United States|Spain 1
United States|Spain|United Kingdom 1
United States|Ukraine 1

Sites per Study

Site_count Study_Count
1 637
2 109
3 57
4 28
5 35
6 16
7 14
8 19
9 12
10 14
11 13
12 12
13 6
14 3
15 11
16 7
17 8
18 4
19 5
20 3
21 6
23 1
24 3
25 3
26 4
27 2
28 2
29 2
30 4
31 2
32 1
33 1
34 1
35 3
36 2
37 1
38 1
39 4
41 1
42 2
43 2
44 1
45 2
46 2
48 3
51 1
53 1
54 2
57 1
59 1
61 2
66 1
68 1
72 2
73 1
74 1
75 1
76 1
77 2
79 2
84 1
89 1
95 1
101 1
103 1
107 1
111 1
115 1
130 1
136 1
137 1
140 1
145 1
146 1
173 1
188 1
201 1
205 1
229 1
234 1
262 1
281 1
366 1
389 1
434 1
534 1
699 1
789 1
807 1
1328 1

Phase

Phase Study_Count
Phase 2 397
Phase 1 264
N/A 201
Phase 1/Phase 2 132
Phase 3 74
Early Phase 1 21
Phase 4 16
Phase 2/Phase 3 14

Number of Arms

Number_of_Arms Count_of_Studies
1 532
2 327
3 56
4 38
5 8
6 10
7 5
8 1
9 3
24 1
37 1
NA 137

Number of Updates

Count of Versions Count of Studies
1 71
2 85
3 112
4 75
5 72
6 61
7 50
8 57
9 60
10 44
11 46
12 38
13 39
14 29
15 18
16 19
17 15
18 24
19 15
20 14
21 10
22 7
23 7
24 11
25 5
26 5
27 11
28 7
29 6
30 4
31 8
32 5
33 6
34 5
35 2
36 4
38 4
39 1
40 2
41 5
42 3
43 2
44 2
46 1
47 1
48 2
49 1
50 8
51 2
52 1
55 1
56 1
59 2
60 1
64 1
66 1
67 2
68 1
70 1
73 1
80 1
85 1
87 1
91 1
95 2
97 1
98 1
100 1
101 1
102 2
108 1
123 2
125 1
136 1
183 1
217 1
221 1
229 1
403 1
565 1
883 1
1228 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 16745 1048 15.978053
Contacts/Locations 7517 945 7.954497
Recruitment Status 1806 925 1.952432
Arms 1661 608 2.731908
Interventions 1661 608 2.731908
Study Design 1530 775 1.974193
Eligibility 1276 587 2.173765
Study Identification 1274 563 2.262877
None (earliest Version on record) 1119 1119 1.000000
Outcome Measures 1111 593 1.873525
Study Description 999 488 2.047131
Sponsor/Collaborators 948 541 1.752311
Conditions 886 388 2.283505
Oversight 730 515 1.417476
References 353 212 1.665094
More Information 190 101 1.881188
Results 155 155 1.000000
IPDSharing 110 104 1.057692
Baseline Characteristics 60 49 1.224490
Results Submission Events 56 56 1.000000
Documents 42 40 1.050000
Participant Flow 35 34 1.029412
Reported Adverse Events 33 29 1.137931

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 8.00000 1.0000 1.00000 2.00000 2.00 20.0000 2.0000 20.00
1st Qu. 14.00000 35.0000 15.00000 25.00000 32.00 98.2500 143.5000 38.75
Median 25.00000 60.0000 25.00000 47.00000 50.00 159.0000 300.0000 86.50
Mean 32.09524 153.5622 35.82422 70.77863 91.65 220.8571 359.3571 164.25
3rd Qu. 30.00000 150.0000 39.00000 80.00000 99.25 245.2500 540.7500 159.50
Max. 108.00000 4606.0000 350.00000 515.00000 6452.00 720.0000 1110.0000 642.00

Trial Group Type

group_type Group_Count
Experimental 1325
Active Comparator 265
NA 137
Other 50
No Intervention 48
Placebo Comparator 45
Sham Comparator 4

Intervention Model

intervention_model Study_Count
Single Group Assignment 611
Parallel Assignment 380
NA 76
Sequential Assignment 30
Crossover Assignment 16
Factorial Assignment 6

Primary Purpose

primary_purpose Study_Count
Treatment 948
Diagnostic 72
Supportive Care 43
Prevention 17
Other 14
Basic Science 10
Health Services Research 6
NA 5
Device Feasibility 3
Screening 1

Observational Studies

Studies by Country

Country Study_Count
United States 88
NA 17
Italy 9
Korea, Republic of 7
Canada 6
Denmark 6
France 6
United Kingdom 5
China 4
Germany 4
Belgium 3
Netherlands 2
Romania 2
Spain 2
United States|Canada 2
Austria 1
Austria|Belgium|France|Germany|Greece|Italy|Netherlands|Poland|Romania 1
Croatia|Italy|Romania 1
Egypt 1
Ireland 1
Ireland|Italy 1
Italy|Romania|Russian Federation|Serbia|Spain|Turkey 1
Pakistan 1
Portugal|Spain 1
Singapore 1
Spain|United Kingdom 1
Sweden 1
Switzerland 1
Taiwan 1
United States|Australia|Austria|Canada|France|Germany|Italy|Spain|Ukraine 1
United States|Canada|Spain|Sweden|United Kingdom 1
United States|Egypt|Germany|Peru|Singapore 1
United States|Spain 1
United States|United Kingdom 1

Sites per Study

Site_count Study_Count
1 141
2 8
3 7
4 6
5 4
7 3
8 2
10 1
12 3
13 2
20 1
22 1
32 1
39 1
118 1

Number of Updates

Count of Versions Count of Studies
1 26
2 24
3 18
4 19
5 14
6 15
7 11
8 8
9 4
10 4
11 5
12 2
13 6
14 3
15 6
16 3
17 1
18 2
21 1
22 1
23 1
24 3
33 1
38 1
49 1
53 1
64 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 1162 156 7.448718
Contacts/Locations 370 116 3.189655
Study Design 186 111 1.675676
None (earliest Version on record) 182 182 1.000000
Recruitment Status 176 111 1.585586
Sponsor/Collaborators 131 73 1.794520
Study Identification 129 76 1.697368
Eligibility 121 64 1.890625
Groups 109 58 1.879310
Interventions 109 58 1.879310
Study Description 102 58 1.758621
Outcome Measures 101 67 1.507463
Oversight 64 52 1.230769
Conditions 52 30 1.733333
References 23 17 1.352941
IPDSharing 19 19 1.000000
More Information 6 3 2.000000
Results 5 5 1.000000
Results Submission Events 2 2 1.000000
Documents 1 1 1.000000

Enrollment Metrics

Measure Observational
Min 5.00
1st Qu 68.25
Median 150.00
Mean 18752.65
3rd Qu 500.00
Max 2323608.00

Observation Model

observational_model Study_Count
Cohort 109
Case-Only 31
Case-Control 19
Other 9
Case Control 4
Family-Based 3
NA 3
Case-Crossover 2
Defined Population 1
Ecologic or Community 1

Time Perspective

time_perspective Study_Count
Prospective 129
Retrospective 33
Cross-Sectional 10
Other 5
NA 4
Longitudinal, Retrospective/Prospective 1

Registries

Studies by Country

Country Study_Count
United States 12
Italy 4
China 3
France 3
Korea, Republic of 3
Germany 2
Romania 2
Sweden 2
Argentina|Australia|Austria|Belgium|Denmark|France|Germany|Italy|Poland|Russian Federation|Singapore|Spain|Switzerland 1
Canada 1
Denmark 1
Japan 1
NA 1
Netherlands 1
Spain 1
Switzerland 1
United Kingdom 1
United States|Canada|Japan|Mexico|Taiwan|United Kingdom 1

Sites per Study

Site_count Study_Count
1 34
4 1
5 1
6 1
16 2
18 1
75 1

Number of Updates

Count of Versions Count of Studies
1 15
2 5
3 4
4 2
5 2
6 7
7 2
8 1
9 1
12 1
16 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 115 26 4.423077
Contacts/Locations 51 21 2.428571
None (earliest Version on record) 41 41 1.000000
Study Design 24 14 1.714286
Recruitment Status 17 12 1.416667
Study Identification 15 6 2.500000
Outcome Measures 12 11 1.090909
Eligibility 11 7 1.571429
Conditions 10 7 1.428571
Study Description 10 7 1.428571
Groups 7 6 1.166667
Interventions 7 6 1.166667
References 7 6 1.166667
Oversight 6 6 1.000000
Sponsor/Collaborators 6 5 1.200000
IPDSharing 5 4 1.250000

Enrollment Metrics

Measure Registries
Min 20.00
1st Qu 100.00
Median 500.00
Mean 25496.83
3rd Qu 1500.00
Max 999999.00

Registry Model

observational_model Study_Count
Cohort 26
Case-Control 8
Case-Only 3
Other 3
Family-Based 1

Time Perspective

time_perspective Study_Count
Prospective 39
Other 2

Follow-up

target_duration Study_Count
2 Years 9
5 Years 7
10 Years 6
1 Year 4
3 Months 3
1 Month 2
6 Months 2
1 Day 1
12 Months 1
15 Years 1
24 Months 1
27 Years 1
30 Days 1
36 Months 1
80 Years 1